Marketing authorization or registration dossiers are required to follow recommendations as described in the EMEA/CVMP/540/03-Rev1 guideline on assessing the stability of antibiotics to be administered in drinking water. However, there are currently no requirements or data available on the compatibility of disinfectants and antibiotics. This article describes the influence on the stability of 10 veterinary products in combination with 50 ppm hydrogen peroxide (H2O2) and sodium hypochlorite (0.5 ppm active chlorine) at two different concentrations (the normal concentration in drinking water, and the concentration when using a stock solution for a proprotioner = 20 x normal concentration).
Materials and method
The following substances were selected for testing:
For each substance, two formulations were chosen (Product 1 and Product 2). Two biocides were selected, being 50 ppm hydrogen peroxide and sodium hypochlorite with 0.5 ppm active chlorine (titrated and depending on pH, up to three times higher in hard water (high pH) than in soft water (low pH) to obtain 0.5 ppm active chlorine).
Two concentration levels were tested:
Stability is expressed as a percentage (%) of the remaining concentration in solution without disinfectants at the same time point.
Results
Only the results after 6 hours are shown. Typically, the results at 6 hours can be extrapolated to 24 hours. For more detailed information, please email [email protected].
Table 1. Activity six hours after dissolution as a percentage (%) of the solution without disinfectant.
Conclusions
Practical advice
Information in this article is sourced from the Cabale project 2020 study. Click on the green button below to open the full article.