Stability of Huvepharma Brands In Acidified Drinking Water

The stability of several water-soluble Huvepharma brands was assessed in acidified drinking water at room temperature for 24 hours after the start of administration. Regional differences in pH values of ground water are often reported.

Table 1. Huvepharma veterinary products included in the stability study. WSP = water soluble powder; OSu = oral suspension; WSG = water soluble granules; OSo = oral solution; MA = microbiological assay; HPLC = high-performance liquid chromatography

The concentration or activity of the active substance(s) was determined at: 

• Three pH values:
  • pH 1.2 = worst case scenario
  • pH 4.5 = standard acidified water
  • pH 7.0 (or 8.0) = tap water
• Three time points:
  • Immediately after the start of administration
  • 6 hours after the start of administration
  • 24 hours after the start of administration

Recovery was expressed as a percentage of the theoretically expected concentration or activity.

Figures 1-12. Recovery expressed as a percentage of the theoretically expected concentration or activity, taking into account the variability of the test method

Conclusion

The twelve brands tested demonstrated excellent recovery in acidified drinking water, even 24 hours after the start of administration. Huvamox® and Huvacillin® demonstrated excellent stability for 24 hours at pH 4.5.

This article is based on Vet Products TB06, linked below.